Single-cell transcriptomics of the kidney reveals unexpected cellular targets of kidney diseases
نویسندگان
چکیده
منابع مشابه
Diseases of the Kidney
permeability, EKG), with less data being presented on histopathological changes (bone marrow, heart, lung, kidneys). It may also be useful in documenting recommendations for maximum permissible doses and similar applications. Because so relatively few scientists in this country read Russian, much of the literature originating in the U.S.S.R. is virtually inaccessible unless translations such as...
متن کاملSingle cell transcriptomics reveals unanticipated features of early hematopoietic precursors
Molecular changes underlying stem cell differentiation are of fundamental interest. scRNA-seq on murine hematopoietic stem cells (HSC) and their progeny MPP1 separated the cells into 3 main clusters with distinct features: active, quiescent, and an un-characterized cluster. Induction of anemia resulted in mobilization of the quiescent to the active cluster and of the early to later stage of cel...
متن کاملSingle-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor
Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer and has very few mutations that are shared between different patients. To better understand the intratumoral genetics underlying mutations of ccRCC, we carried out single-cell exome sequencing on a ccRCC tumor and its adjacent kidney tissue. Our data indicate that this tumor was unlikely to have resulted from mutations in ...
متن کاملSingle-cell transcriptomics reveals receptor transformations during olfactory neurogenesis.
The sense of smell allows chemicals to be perceived as diverse scents. We used single-neuron RNA sequencing to explore the developmental mechanisms that shape this ability as nasal olfactory neurons mature in mice. Most mature neurons expressed only one of the ~1000 odorant receptor genes (Olfrs) available, and at a high level. However, many immature neurons expressed low levels of multiple Olf...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2018
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.wcp2018.0_sy10-2